Expression of nuclear export factor CRM1 and p27 in glioma.
- Author:
Dong-Lin WANG
1
;
Yu-Chan WANG
;
Peng LU
;
Qun E
;
Gong-Sheng SHI
Author Information
- Publication Type:Journal Article
- MeSH: Active Transport, Cell Nucleus; genetics; Adolescent; Adult; Aged; Brain Neoplasms; genetics; metabolism; Child; Cyclin-Dependent Kinase Inhibitor p27; genetics; metabolism; Gene Expression Regulation, Neoplastic; Glioma; genetics; metabolism; Humans; Middle Aged; Nuclear Export Signals; genetics; Phosphorylation; Prognosis; Young Adult
- From: Chinese Journal of Pathology 2008;37(7):454-457
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of nuclear export factor CRM1, Ser10-phosphorylated p27 and p27 in human gliomas.
METHODSThe expression of CRM1, Ser10-phosphorylated p27 and p27 were investigated in 70 cases of human gliomas and 10 specimens of the normal brain tissue by immunohistochemical technique and Western blot.
RESULTSThere were significant differences on the expression levels of CRM1, Ser10-phosphorylated p27 and p27 among normal brain tissue, gliomas of grades II and gliomas of grades III plus IV (P < 0.01). The expression of CRM1 in gliomas was inversely correlated with the expression of p27 (r(s) = -0.727, P < 0.01) and positively correlated with the expression of Ser10-phosphorylated p27 (r(s) = 0.954, P < 0.01) and Ki-67 (r(s) = 0.799, P < 0.01). Moreover, the expression of Ser10-phosphorylated p27 was inversely correlated with p27 (r(s) = -0.744, P < 0.01) and positively correlated with Ki-67 (r(s) = 0.785, P < 0.01).
CONCLUSIONSCRM1, through recognizing and binding with Ser10-phosphorylated p27, may promote moving of p27CRM1 from its original locating sites; act as a critical signaling component in the proliferative process of glioma cells and then, plays an important role in the development of gliomas.
