Study of severe hepatitis treated with a hybrid artificial liver support system.
- Author:
Lan-juan LI
1
;
Qian YANG
;
Jian-rong HUANG
;
Jun LI
;
Hong-cui CAO
;
Yue-mei CHEN
;
Ya-gang CHEN
;
Ji-fang CHENG
;
Su-zhen FU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Animals; Animals, Newborn; Bioreactors; Female; Hepatitis B, Chronic; complications; therapy; Humans; Liver Failure; therapy; Liver, Artificial; Male; Middle Aged; Plasma Exchange; instrumentation; methods; Swine; Swine, Miniature; Treatment Outcome
- From: Chinese Journal of Hepatology 2003;11(8):458-460
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo evaluate the efficacy of a hybrid artificial liver support system in the treatment of chronic severe hepatitis.
METHODSThe hybrid artificial liver support system (HALSS) consisted of a bioreactor containing more than 5 x 10(9) porcine hepatocytes and plasma exchange device. 15 patients with chronic severe viral hepatitis were treated with the hybrid system.
RESULTSAll the patients experienced a reduction in symptoms, such as fatigue, abdominal distention or ascites. After each treatment serum total bilirubin decreased markedly (from 493.5 micromol/L+-139.8 micromol/L to 250.9 micromol/L+-91.3 micromol/L, t=8.695, P<0.001), while prothrombin activity increased (from 24.5%+-8.4% to 30.6%+-6.3%, t=3.325, P<0.01). There were 11 patients whose progress of hepatocytes necrosis stopped after HALSS treatment, and finally they recovered completely. Four patients died of their worsen conditions. No serious adverse events were noted in the 15 patients.
CONCLUSIONHALSS is a reliable hepatic support device for chronic severe hepatitis.
