Preliminary evaluation on the effects of a hybrid bioartificial liver support system in the treatment of hepatic failure.
- Author:
Ying-jie WANG
1
;
Nian-hai HE
;
Run-zhang NIU
;
Jun LIU
;
Hong-wei WEN
;
Jia-jia LI
;
Yu-ming WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Bioreactors; Cells, Cultured; Charcoal; Female; Hemofiltration; instrumentation; methods; Hemoperfusion; instrumentation; methods; Hepatocytes; cytology; Humans; Liver Failure, Acute; physiopathology; therapy; Liver, Artificial; Male; Middle Aged; Sorption Detoxification; instrumentation; methods; Treatment Outcome
- From: Chinese Journal of Hepatology 2003;11(8):461-463
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo construct a novel hybrid artificial liver support system and evaluate its clinical efficacy in the treatment of hepatic failure.
METHODSA hybrid bioartificial liver support system consisting of plasma exchange device, charcoal perfusion column, and bioreactor cultured human or porcine hepatocytes was developed. 30 patients with hepatic failure were treated using this hybrid system.
RESULTSBoth the excellent rate and effectual rate of the artificial liver support system were 43.3% (13/30). The total effectual rate was 86.7%. Finally, eleven out of 30 patients recovered completely. Six patients were bridged to liver transplantation. Six patients (20%) died of hepatic failure and seven patients (23.3%) discharged due to worsening of disease.
CONCLUSIONSThe hybrid artificial liver support system has prominent liver support effects for hepatic failure, which can be regarded as an efficient measure for the treatment of severe hepatitis.
