Sperm DNA damage and unexplained recurrent spontaneous abortion.
- Author:
Cheng-Jun LIU
1
;
Ai-Ming WANG
;
Wei SHANG
;
Min LI
;
Wei-Zhou WANG
;
Yu-Liang SHEN
;
Yong ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Habitual; etiology; Adult; Case-Control Studies; DNA Damage; DNA Fragmentation; Female; Humans; Male; Pregnancy; Spermatozoa; pathology
- From: National Journal of Andrology 2011;17(7):619-621
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship of sperm DNA damage with unexplained recurrent spontaneous abortion (URSA).
METHODSSperm DNA fragmentation was evaluated by sperm chromatin dispersion (SCD), and the results were expressed in terms of DNA fragmentation index (DFI). DFIs were measured in the male partners of 56 women with URSA (the experiment group) and of 31 without URSA (the control group).
RESULTSThe DFI was shown to be (11.0% - 56.9%) in the experiment group, 21 (37.5%) of the subjects over 30%, as compared with (10.0% -36.8%) in the control group, only 8 (25.8%) of the subjects over 30%, significantly higher in the former than in the latter (29.4% vs 25.5%, P < 0.05).
CONCLUSIONThere is a relationship between sperm DNA damage and URSA.
