Expression of ID3 protein in prostate cancer and its clinicopathological significance.
- Author:
Kai WANG
1
;
Xiao-jun LI
;
Hong-lin YIN
;
Hang-bo ZHOU
;
Fang-fang CHEN
;
Hai WANG
;
Heng-hui MA
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Fluoroimmunoassay; Humans; Immunohistochemistry; Inhibitor of Differentiation Proteins; metabolism; Male; Middle Aged; Neoplasm Proteins; metabolism; Prostatic Neoplasms; metabolism; pathology
- From: National Journal of Andrology 2011;17(5):410-413
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of the ID3 protein in prostate cancer and its clinicopathological significance.
METHODSWe detected the expression of the ID3 protein in PC-3M cells by indirect immunofluorescence, and that in 29 prostate cancer and 15 prostate hyperplasia specimens by immunohistochemistry. Then we analyzed the correlation between the expression level of ID3 and the clinicopathological parameters.
RESULTSThe ID3 protein was expressed predominantly in the nucleus of PC-3M cells. Its expression rate was 82.7% (24/29) in the prostate cancer specimens, significantly higher than 6.6% (1/15) in prostate hyperplasia (P < 0.05), and was positively correlated with the Gleason score of prostate cancer (P < 0.05).
CONCLUSIONThe ID3 protein is expressed in prostate cancer, and is elevated with the increase of Gleason score.
