Differentially expressed genes in asthenospermia: a bioinformatics-based study.
- Author:
Xiang-Ming MAO
1
;
Rong-Wei XING
;
Xiao-Wei JING
;
Qi-Zhao ZHOU
;
Qing-Feng YU
;
Wen-Bin GUO
;
Xiao-Qiang WU
;
Qing-Jun CHU
;
Chun-Qiong FENG
Author Information
- Publication Type:Journal Article
- MeSH: Asthenozoospermia; genetics; metabolism; Computational Biology; Databases, Genetic; Gene Expression Profiling; Humans; Male; Oligonucleotide Array Sequence Analysis; Spermatozoa; metabolism
- From: National Journal of Andrology 2011;17(8):694-698
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the differentially expressed genes in asthenospermia to gain a deeper insight into the molecular mechanisms of the disease.
METHODSWe analyzed the differentially expressed genes in asthenospermia using GATHER, PANTHER and ToppGene online bioinformatics tools.
RESULTSOur bioinformatics mining and analyses revealed that the differentially expressed genes in asthenospermia played important roles in the cellular protein and macromolecular metabolism, protein modification, cell death, cell apoptosis and apoptosis induction.
CONCLUSIONAsthenospermia patients experience a decline in sperm activity and the basic life activities of sperm simultaneously, and are also prone to cell apoptosis or death. Such differentially expressed genes as KIF3B, MYO15A, KIF6, KIF26B, KIF3A, DNHD2, DMN, DYNC2H1, STARD9, MYOHD1, and TPM1, which are involved in cytoskeletal structure, microtubule movement and cell movement, may be associated with asthenospermia, and therefore deserve further studies.
