Association of IL-6-572C > G polymorphism with the susceptibility to prostate cancer in the Chinese Han population in Jiangsu and Anhui area.
- Author:
Xiao-Ming LU
1
;
Li-Xin HUA
;
Jin-Feng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; epidemiology; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-6; genetics; Male; Polymorphism, Single Nucleotide; Prostatic Neoplasms; epidemiology; genetics
- From: National Journal of Andrology 2011;17(8):707-711
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of the IL-6 -572C > G polymorphism with the risk of prostate cancer (PCa) in the Chinese Han population in Jiangsu and Anhui area.
METHODSWe obtained peripheral blood genome DNA from 200 PCa patients and 279 age-matched PCa-free healthy controls, analyzed the site polymorphism of IL-6 -572C > G with the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, and studied the correlation of different genotypes with the susceptibility to PCa.
RESULTSThe subjects that carried the CCGG genotype had a risk of PCa 2.46 times that of the CC genotype carriers (95% CI = 1.41-4.29), and 2.47 times that of the CC/GC genotype carriers (95% CI = 1.47-4.17). This risk was significantly increased among the following subgroups of CCGG genotype carriers: age > 70 yr (OR = 3.06, 95% CI: 1.44-6.49), BMI > 23 kg/m2 (OR = 3.72, 95% CI: 1.79-7.74), no cigarette smoking (OR = 2.96, 95% CI: 1.30-6.72), alcohol drinking (OR = 2.73, 95% CI: 1.28-5.79), with a family history of cancer (OR = 6.67, 95% CI: 1.50-29.69).
CONCLUSIONIn the Chinese Han population in Jiangsu and Anhui area, IL-6 -572C > G polymorphism is associated with the susceptibility to PCa, and GG might be a susceptible genotype to PCa.
