Expressions of integrinalpha2beta1 and CD133 in benign prostatic hyperplasia complicated by prostatitis and their significance.
- Author:
Qi DING
1
;
Wen-long MIAO
;
Shuo LIU
;
Ji-wu CHANG
;
Yu-ming YANG
Author Information
- Publication Type:Journal Article
- MeSH: AC133 Antigen; Antigens, CD; metabolism; Glycoproteins; metabolism; Humans; Inflammation; metabolism; Integrin alpha2beta1; metabolism; Male; Peptides; metabolism; Prostatic Hyperplasia; complications; metabolism; pathology; Prostatitis; complications; metabolism; pathology
- From: National Journal of Andrology 2011;17(10):909-912
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expressions of Integrinalpha2beta1 and CD133 in benign prostatic hyperplasia (BPH) complicated by prostatitis and their significance.
METHODSSpecimens were obtained from 56 BPH patients undergoing transvesical prostatectomy. Paraffin sections of the specimens were subjected to HE staining for pathological examination of inflammatory changes under the light microscope. Twenty-four patients with simple BPH were included in Group A, and the other 32 with BPH complicated with prostatitis in Group B. The expressions of Integrinalpha2beta1 and CD133 in the prostatic tissues of the two groups were determined by immunohistochemistry, Western blotting and IPP6.0 image analysis software.
RESULTSThe expressions of Integrinalpha2beta1 and CD133 were significantly higher in Group B than in A (P < 0.05), and so were the mean relative value of the optical density of Integrinalpha2beta1 (0.29 +/- 0.18 vs 0.04 +/- 0.03) and that of CD133 (0.08 +/- 0.07 vs 0.0020 +/- 0.0018) (P < 0.05).
CONCLUSIONInflammation can up-regulate the expressions of Integrinalpha2beta1 and CD133 in BPH tissue.
