Lack of association between the LRRK2 A419V variant and Asian Parkinson's disease.
- Author:
Aroma Agape GOPALAI
1
;
Shen Yang LIM
;
Zariah Abdul AZIZ
;
Soo Kun LIM
;
Li Ping TAN
;
Yip Boon CHONG
;
Chong Tin TAN
;
Santhi PUVANARAJAH
;
Shanti VISWANATHAN
;
Rishikesan KUPPUSAMY
;
Ai Huey TAN
;
Thien Thien LIM
;
Gaik Bee EOW
;
Mohamed Ibrahim NORLINAH
;
Hui Hua LI
;
Yi ZHAO
;
Azlina AHMAD-ANNUAR
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; genetics; Case-Control Studies; China; ethnology; Cohort Studies; Cytosine; Female; Gene Frequency; Genetic Variation; genetics; Genotype; Heterozygote; Humans; India; ethnology; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Malaysia; ethnology; Male; Middle Aged; Parkinson Disease; genetics; Polymorphism, Genetic; genetics; Protein-Serine-Threonine Kinases; genetics; Risk Factors; Singapore; Thymine; Valine; genetics; Young Adult
- From:Annals of the Academy of Medicine, Singapore 2013;42(5):237-240
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONThe G2385R and R1628P LRRK2 gene variants have been associated with an increased risk of Parkinson's disease (PD) in the Asian population. Recently, a new LRRK2 gene variant, A419V, was reported to be a third risk variant for PD in Asian patients. Our objective was to investigate this finding in our cohort of Asian subjects.
MATERIALS AND METHODSEight hundred and twenty-eight subjects (404 PD patients, and 424 age and gender-matched control subjects without neurological disorders) were recruited. Genotyping was done by Taqman® allelic discrimination assay on an Applied Biosystems 7500 Fast Real-Time PCR machine.
RESULTSThe heterozygous A419V genotype was found in only 1 patient with PD, compared to 3 in the control group (0.4% vs 1.3%), giving an odds ratio of 0.35 (95% confidence interval (CI), 0.01 to 3.79; P = 0.624).
CONCLUSIONA419V is not an important LRRK2 risk variant in our Asian cohort of patients with PD. Our data are further supported by a literature review which showed that 4 out of 6 published studies reported a negative association of this variant in PD.
