Mechanism of changes in intestinal epithelium permeability and its countermeasure after burn injury.
- Author:
Shi-liang WANG
1
Author Information
1. Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Burns;
metabolism;
Intestinal Mucosa;
metabolism;
Intestines;
metabolism;
Membrane Proteins;
metabolism;
Myosin Light Chains;
metabolism;
Permeability;
Phosphoproteins;
metabolism;
Phosphorylation;
Rats;
Zonula Occludens-1 Protein;
rho-Associated Kinases;
metabolism
- From:
Chinese Journal of Burns
2010;26(5):334-335
- CountryChina
- Language:Chinese
-
Abstract:
After a series of studies, we found that the intestinal permeability was increased, tight junction protein (zonula occluden-1) obviously decreased and redistributed, accompanied by an increase in expression of myosin light chain (MLC) phosphorylation in severely burned rats. After using inhibitor of MLC kinase (ML-9 2 mg/kg) or of Rho-associated kinase (Y-27632 2 mg/kg), above-mentioned changes could be alleviated. Therefore, to regulate the MLC phosphorylation of tight junction protein and perijunctional actin-myosin ring may be one of the key links to lessen the intestinal epithelium permeability after burn injury.
