Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors.
- Author:
Shu-xiang WANG
1
;
Hong SHANG
;
Xiao-xu HAN
;
Zi-ning ZHANG
;
Ya-nan WANG
;
Min ZHANG
;
Yong-jun JIANG
;
Jing LIU
;
Yan-li SU
Author Information
- Publication Type:Journal Article
- MeSH: Chemokine CXCL12; genetics; China; Gene Frequency; Genotype; HIV Infections; genetics; pathology; virology; HIV Long-Term Survivors; HIV-1; physiology; Host-Pathogen Interactions; Humans; Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Receptors, CCR2; genetics; Receptors, CCR5; genetics; Receptors, HIV; genetics
- From: Chinese Journal of Experimental and Clinical Virology 2006;20(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression.
METHODSThe genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs).
RESULTSThe frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs.
CONCLUSIONVariant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs.
