Analysis of human H5N1 virus hemagglutinin gene isolated from the mainland of China.
- Author:
Yue-long SHU
1
;
Yu LAN
;
Le-ying WEN
;
Xin-sheng ZHAO
;
Ye ZHANG
;
Jie DONG
;
Shu-min DUAN
;
Kai NIE
;
Xiao-guang ZHANG
;
Da-yan WANG
;
Li-hong YAO
;
Yuan-ji GUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chick Embryo; China; Hemagglutinin Glycoproteins, Influenza Virus; genetics; Humans; Influenza A Virus, H5N1 Subtype; classification; genetics; isolation & purification; Influenza, Human; virology; Phylogeny; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA
- From: Chinese Journal of Experimental and Clinical Virology 2006;20(2):8-10
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo analyze the genetic and antigenic characteristics of human H5N1 virus isolated from the mainland of China.
METHODSThe hemagglutinin (HA) gene of human H5N1 virus were sequenced and analyzed.
RESULTSThe results of HA gene sequencing showed that all the virus isolates belong to the same group because of the high similarity, but they were different from the virus isolated from Thailand and Vietnam. The sequence data also showed that the receptor specificity and the connecting peptide between HA1 and HA2 are still avian influenza origin.
CONCLUSIONThe virus isolates from mainland of China until now belong to the same group and are different from the virus isolated from Thailand and Vietnam, and there is no evidence showing the human-avian influenza reassortant and recombination.
