Laboratory diagnoses of the first confirmed human case of avian influenza A (H5N1) in the mainland of China.
- Author:
Jie DONG
1
;
Hong ZHANG
;
Yun-zhi LIU
;
Ye ZHANG
;
Min WANG
;
Hong-jie YU
;
Wei-zhong YANG
;
Cui-ling XU
;
Ni-juan XIANG
;
Zhong-jie LI
;
Yu-xu CHEN
;
Yuan-ji GUO
;
De-xin LI
;
Jun-hua LI
;
Yu WANG
;
Yue-long SHU
Author Information
- Publication Type:Case Reports
- MeSH: Animals; Antibodies, Viral; blood; Cell Line; Chick Embryo; Child; China; Clinical Laboratory Techniques; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus; genetics; immunology; Humans; Influenza A Virus, H5N1 Subtype; genetics; immunology; isolation & purification; Influenza, Human; diagnosis; virology; Male; Neutralization Tests; Pneumonia, Viral; diagnosis; virology; Reagent Kits, Diagnostic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA
- From: Chinese Journal of Experimental and Clinical Virology 2006;20(2):14-16
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo determine the etiologic agent of an atypical pneumonia human case admitted to Xiangtan City hospital, Hunan Province in Oct. 2005.
METHODSThe patient's respiratory tract samples and serum were collected. Throat swabs were tested by microneutralization and hemagglutination-inhibition assays.
RESULTSThe results of nucleic acid detection of all respiratory samples were negative and virus isolation was also negative. The H5-specific antibodies of convalescence showed a 4-fold greater rise than acute phase.
CONCLUSIONThe atypical pneumonias case was confirmed as the first human case of avian influenza A (H5N1) infection in the mainland of China.
