Adamantane resistance among influenza A (H3N2) viruses isolated from the mainland of China.
- Author:
Yu LAN
1
;
Zi LI
;
Li-bo DONG
;
Ye ZHANG
;
Le-ying WEN
;
Yan-ming ZHANG
;
Min WANG
;
Yuan-ji GUO
;
Yue-long SHU
Author Information
- Publication Type:Journal Article
- MeSH: Adamantane; pharmacology; Animals; Antiviral Agents; pharmacology; Chick Embryo; China; Drug Resistance, Viral; Influenza A Virus, H3N2 Subtype; drug effects; genetics; isolation & purification; RNA, Viral; genetics; isolation & purification; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Viral Matrix Proteins; genetics
- From: Chinese Journal of Experimental and Clinical Virology 2006;20(2):21-23
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo study the incidence of adamantane resistance among influenza A (H3N2) viruses isolated from the mainland of China since 1989 through our influenza surveillance system, and to provide more information for the clinical usage of adamantane drugs.
METHODSTotally 584 influenza A (H3N2) virus strains were randomly selected from our surveillance network since 1989, the adamantane drug resistance related gene M2 of all 584 strains was sequenced, and the drug sensitivity of viruses was also assayed by using biological methods in cells.
RESULTSNo adamantane resistant strains were detected among the strains isolated from 1989 to 1999, but there was a surprisingly increased resistance rate of 56% in 2003 compared with 3.4% in 2002, and in 2005 the resistance rate increased to 77.6%.
CONCLUSIONOver 50% of virus among the strains isolated showed adamantane resistance since 2003, and the incidence rate is increasing.
