Epidemiologic study and HLA analysis of highly exposed to HIV but persistently seronegative subjects (HEPS) in commercial blood donors in China.
- Author:
Ke-yi XU
1
;
Tao DONG
;
Wen-hui LUN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Blood Donors; China; epidemiology; Cohort Studies; Female; HIV; immunology; HIV Antibodies; blood; HIV Infections; epidemiology; virology; HIV Seronegativity; HLA Antigens; genetics; HLA-A Antigens; genetics; HLA-A24 Antigen; Histocompatibility Testing; methods; Humans; Male; Middle Aged; Polymerase Chain Reaction; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2006;20(2):72-74
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUNDTo investigate epidemiology and HLA typing of highly exposed to HIV but persistently seronegative subjects (HEPS) in commercial blood donors in China.
METHODSThis was a cohort study for epidemiologic characteristics of highly exposed but persistently seronegative subjects. PCR with sequence-specific primer and PCR-SSP for HLA typing were applied.
RESULTSEight HEPS were identified. Compared HLA typing with seropositive couple, high frequency of HLA-a24, HLA-B40 genotyping was observed.
CONCLUSIONHighly exposed to HIV but persistently seronegative subjects in commercial blood donors in China had high frequency of HLA-A24 and HLA-B40 genotype.
