Difference in the CD4+T lymphocytes activation between long term non-progressors and typical progressors of HIV-1 infected patients.
- Author:
Yan-mei JIAO
1
;
Jun-liang FU
;
Zheng ZHANG
;
Hui ZHANG
;
Lei JIN
;
Chun-bao ZHOU
;
Bao-yun FU
;
Fu-sheng WANG
;
Hao WU
Author Information
- Publication Type:Journal Article
- MeSH: ADP-ribosyl Cyclase 1; analysis; Adult; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; cytology; immunology; Female; Flow Cytometry; HIV Infections; blood; immunology; virology; HIV-1; genetics; physiology; Host-Pathogen Interactions; Humans; Lymphocyte Activation; immunology; Male; Middle Aged; RNA, Viral; blood; Time Factors; Viral Load; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the difference in the CD4+T lymphocytes activation between long term non progressors (LTNP) and typical progressors (TP) of HIV-1 infected patients.
METHODSTwenty-four HIV-1 infected patients and 15 heathy control adults were tested and flow cytometry was used to detect the activation marker CD38 and CD4 count in blood samples taken from the patients and control. bDNA method was used to test the virus load in the plasma of patients.
RESULTSThe activation of CD4+T cells was positively correlated with virus load and negatively correlated with CD4 counts. Compared with normal controls, the activation of CD4+T cells was obviously increased in TP patients but not obviously changed in LTNP patients.
CONCLUSIONCompared with healthy controls, the activation of CD4+T cells in LTNP did not obviously increase. This maybe partially accounts for LTNP patients keeping a good state for a long time.
