Effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine and its safety.
- Author:
Chuan-xiu BIAN
1
;
Shu-de JIANG
;
Jian-yong YANG
;
Ming-bo SUN
;
Ming-xue XIE
;
Xin-wen ZHANG
;
Guo-yang LIAO
;
Wei-dong LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Anti-Infective Agents, Local; administration & dosage; pharmacology; toxicity; Antigens, Viral; analysis; immunology; Body Weight; drug effects; Cercopithecus aethiops; Drug Stability; Enzyme-Linked Immunosorbent Assay; Ethylene Glycols; administration & dosage; pharmacology; toxicity; Guinea Pigs; Mice; Neutralization Tests; Poliovirus Vaccine, Inactivated; administration & dosage; immunology; toxicity; Vero Cells
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(1):44-46
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of 2-phenoxyethanol on potency of Sabin inactivated poliomyelitis vaccine (IPV).
METHODSSabin IPV samples containing 5 mg or 7 mg 2-phenoxyethanol each dosage respectively were placed separately at 4 degrees C, 37 degrees C for 2 days and 7 days. D-antigen contents were tested with ELISA method. Then neutralizing antibodies in mice and guinea pigs were detected. The safety experiment was performed according to unusual toxicity test of China requirement for biological product.
RESULTSAfter addition of 2-phenoxyethanol, the I, II, and III D-antigen contents of Sabin IPV did not change. The antibody levels in mice and guinea pigs were not different between experimental group and control group. Animals were safe during observation period.
CONCLUSION2-Phenoxyethanol had no effect on potency and safety of Sabin IPV. It can be used as antiseptic for Sabin IPV.
