Experimental studies on treatment of HSV infections with photodynamic therapy using 5-aminolevulinic acid.
- Author:
Ji-ning TAO
1
;
Shu-min DUAN
;
Jun LI
Author Information
- Publication Type:Journal Article
- MeSH: Aminolevulinic Acid; therapeutic use; Animals; Cercopithecus aethiops; Disease Models, Animal; Female; Guinea Pigs; Herpes Simplex; drug therapy; virology; Male; Photochemotherapy; Random Allocation; Simplexvirus; drug effects; Skin Diseases, Viral; drug therapy; Treatment Outcome; Vero Cells
- From: Chinese Journal of Experimental and Clinical Virology 2007;21(1):79-82
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate in vitro and in vivo anti-human herpes simplex virus effects of photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA).
METHODSGuinea pigs model of cutaneous herpes virus infection was applied, and Vero cells infected by HSV-I and HSV-II were used as experimental systems to observe the antiherpes effect of ALA-PDT.
RESULTSThe in vitro experiments showed that ALA-PDT has antiherpes effect on HSV-I and HSV-II, its effect was similar to that of acyclovir. The results of animal experiments showed that ALA-PDT had significant therapeutic effect on guinea pigs model of cutaneous herpes virus infection, the effect was dose-related.
CONCLUSIONALA-PDT could be effective in treating HSV infections, which may provide a new approach to the treatment of viral infections.
