Association between pemphigus vulgaris and human leukocyte antigen in Han nation of northeast China.
- Author:
Long GENG
1
;
Yan WANG
;
Ning ZHAI
;
Ya-Ni LU
;
Fang-Ji SONG
;
Hong-Duo CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; ethnology; China; ethnology; Female; Gene Frequency; HLA-A Antigens; genetics; HLA-A3 Antigen; genetics; HLA-B Antigens; genetics; HLA-DQ Antigens; genetics; HLA-DQ beta-Chains; HLA-DR Antigens; genetics; HLA-DRB1 Chains; Humans; Male; Middle Aged; Pemphigus; genetics; Phenotype
- From: Chinese Medical Sciences Journal 2005;20(3):166-170
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the relationship between pemphigus vulgaris (PV) and human leukocyte antigen (HLA) in Han nation of northeast China.
METHODSStandard microcytotoxicity test and polymerase chain reaction-sequence specific primers method were used to detect the HLA class I antigens and HLA-DRB1 and DQB1 alleles in 27 patients with PV and results were compared with control group.
RESULTSGene and phenotype frequencies of HLA-A3, A26(10), B60(40), and B13 (27.99%, 48%; 16.11%, 30%; 23.02%, 41%; 16.11%, 30%, respectively) increased significantly in PV group compared with control (1.01%, 2%; 0.5%, 1%; 4.61%, 9%; 5.13%, 10%, respectively). After P value correction, the difference of A3, A26 (10), and B60 (40) between the two groups was still significant. The gene frequencies of HLA-DRB1*140x (1401, 1404, 1405, 1407, 1408), DRB1*120x, and DQB1*0503 alleles in PV group (42.26%, 25.46%, and 23.02%) were significantly higher than control group (5.09%, 7.74%, and 1.89%). After P value correction, the difference was still significant between the two groups.
CONCLUSIONPV significantly relates with HLA in PV patients of Han nation of northeast China.
