Urine metabonomic study on long-term use of total ginsenosides in rats.
- Author:
Xie XIE
;
Shao-Qiu CHEN
;
Ying-Fang LV
;
Xiao-Yan WANG
;
Wei JIA
- Publication Type:Journal Article
- MeSH:
Animals;
Drugs, Chinese Herbal;
metabolism;
Ginsenosides;
metabolism;
urine;
Male;
Metabolomics;
Panax;
metabolism;
Rats;
Rats, Wistar;
Time Factors
- From:
China Journal of Chinese Materia Medica
2014;39(23):4675-4679
- CountryChina
- Language:Chinese
-
Abstract:
Due to its effect of systems regulation and promotion on body, Ginseng is always referred to be long-term used as a dietary supplement. But it was still unclear about its target of the tonic effects and also the side-effects long-term use may bring. Urine metabolomic method is suitable for long-term studies of pharmaco-dynamics, pharmacology and toxicology of traditional Chinese medicine because of its characteristics of non-invasive and monitoring the whole-body metabolism. This study was designed to detect the dynamic variation of rat urine metabolome along with a long-term administration of total ginsenosides using GC-TOF based metabolomic technology. Our result showed that either short-term or chronic administration of ginsenosides did not impact the rat urine metabolome significantly (as the PCA subgroup was not successful). By comparison, the short-term (1-3 w) dose of ginsenosides had the biggest metabolic influence including TCA cycle, catecholamines and neurotransmitter amino acids. Medium-term (6-10 w) dose had a gradually lower effect and long-term (27 w) dose almost had no effect. Our study indicates that both short and long-term administration of ginsenosides showed almost no obvious side-effect on the experimental animals.
