Advances on pharmacokinetics of traditional Chinese medicine under disease states.
- Author:
Zi-peng GONG
;
Ying CHEN
;
Rui-jie ZHANG
;
Qing YANG
;
Xiao-xin ZHU
- Publication Type:Journal Article
- MeSH:
Animals;
Brain Ischemia;
drug therapy;
Chemical and Drug Induced Liver Injury;
drug therapy;
Humans;
Inflammation;
drug therapy;
Medicine, Chinese Traditional;
Nervous System Diseases;
drug therapy
- From:
China Journal of Chinese Materia Medica
2015;40(2):169-173
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, more and more research shows that the pharmacokinetic parameter of traditional Chinese medicine can be affected by the disease states. It's possible that drug metabolic enzymes, transporters, cell membrane permeability and the change of microbes group could be interfered with physiological and pathological changes, which enables the pharmacokinetics of traditional Chinese medicine in the body to be altered, including the process of absorption, distribution, metabolism and excretion, and then the pharmacokinetic parameters of traditional chinese medicine are altered. It's found that investigating the pharmacokinetic of traditional Chinese medicine in the pathological state is more useful than that of in normal state because the great part of traditional Chinese medicine is mainly used to treat disease. This article reflects the latest research on the pharmacokinetic of traditional Chinese medicine in the disease state such as diabete, cerebral ischemia, liver injury, inflammatory disease, nervous system disorders and fever in order to provide certain reference for clinicians designing reasonable administration dose.
