Research progress on hypoglycemic effect and its mechanism of action of medicinal fungal polysaccharides.
- Author:
Rong DAI
;
Ru-ming LIU
;
Jian-hui XIAO
- Publication Type:Journal Article
- MeSH:
Animals;
Carbohydrate Metabolism;
drug effects;
Fungal Polysaccharides;
pharmacology;
Humans;
Hypoglycemic Agents;
pharmacology;
Insulin Resistance;
Insulin-Secreting Cells;
drug effects;
Oxidative Stress;
drug effects
- From:
China Journal of Chinese Materia Medica
2015;40(2):174-179
- CountryChina
- Language:Chinese
-
Abstract:
Due to substantial morbidity and high complications, diabetes mellitus is considered as the third "killer" in the world. Medicinal fungal polysaccharides, as water-soluble macromolecular substances with low toxicity, exhibit diversified pharmacological actions such as immune regulation, anti-tumor, antivirus, antioxidant, anti-aging, hypoglycemic effect and improving liver and kidney function. In recent year, a number of investigators reported medicinal fungal polysaccharides showed good anti-diabetes and hypoglycemic activity, and their acting mechanisms involved in glycometabolism and β cell function, e. g. promoting glycogen synthesis, promoting glycolysis, inhibiting the activity of α-glucosidase, promoting insulin secretion, increasing insulin sensitivity, enhancing antioxidation. Therefore, the hypoglycemic activity and its mechanisms of action of medicinal fungal polysaccharides showed characteristics of multiple effects, multi-target, and multi-pathway regulation. These finding suggest that medicinal fungal polysaccharides are a promising source for the development of discovery of anti-diabetic agent.
