Nonexpressor of pathogenesis-related genes 1 (NPR1): a key node of plant disease resistance signalling network.
- Author:
Hong-Zhi ZHANG
1
;
Xin-Zhong CAI
Author Information
1. Institute of Biotechnology, and Department of Plant Protection, Zhejiang University, Hangzhou 310029, China.
- Publication Type:Journal Article
- MeSH:
Arabidopsis Proteins;
genetics;
Cyclopentanes;
metabolism;
pharmacology;
Gene Expression Regulation, Plant;
genetics;
Oxylipins;
metabolism;
pharmacology;
Plant Diseases;
genetics;
Plants, Genetically Modified;
Salicylic Acid;
metabolism;
pharmacology;
Signal Transduction
- From:
Chinese Journal of Biotechnology
2005;21(4):511-515
- CountryChina
- Language:Chinese
-
Abstract:
The NPRI (nonexpressor of pathogenesis-related genes (1) gene, firstly cloned in Arabidopsis thaliana, is a key gene involved in regulation of plant disease resistance. It plays a pivotal role not only in systemic acquired resistance (SAR) and induced systemic resistance (ISR), but also in basic resistance and resistance (R) gene-dependent resistance. NPR1 monomerization induced by enhanced reducing condition after oxidative burst, and the accumulation of NPR1 monomers in the nuclei, are required and enough for expression of PR (pathogenesis-related) genes and SAR. NPR1 regulates PR gene expression through interaction with TGA transcription factors (TF). As a cross-talk point of a variety of defense signaling pathways, probably through direct or indirect interacting with some WRKY TFs and a NPR1-like protein NPR4, NPR1 is essential in balancing salicylic acid- and jasmonic acid- dependent signal transduction pathways, which is achieved through an unknown mechanism in the cytosol. The possible application of NPR1 in plant protection is also discussed in this review.
