Administration of low-dose heparin in total nutrient admixture prevents central venous catheter-related infections in neonates.
- Author:
Jun TANG
1
;
Xi-Hong LI
;
Hua WANG
;
Ying XIONG
;
De-Zhi MU
Author Information
- Publication Type:Journal Article
- MeSH: Catheter-Related Infections; epidemiology; prevention & control; Catheterization, Central Venous; adverse effects; Female; Heparin; administration & dosage; Humans; Incidence; Infant, Newborn; Male; Parenteral Nutrition, Total; Retrospective Studies
- From: Chinese Journal of Contemporary Pediatrics 2009;11(12):983-985
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEPeripherally inserted central catheter (PICC) is widely used to provide a long-term access for the administration of total parenteral nutrition and medications. Catheter-related infections (CRI) are common complications of PICC. The purpose of this retrospective study was to investigate the role of low-dose heparin added to the total nutrient admixture (CTNA) in the prevention of CRI.
METHODSEighty-three neonates who underwent PICC received TNA with (heparin group, n=43) or without heparin (0.5 U/mL) (control group, n=40). The incidence of CRI was compared between the two groups.
RESULTSThe incidences of catheter obstruction (5% vs 20%) and the catheter-tip colonization (2% vs 18%) in the heparin group were significantly lower than those in the control group (p<0.05). None of the neonates in the heparin group had clinical evidence of catheter-related bloodstream infection, but 5 cases in the control group (p<0.05).
CONCLUSIONSThe administration of low-dose heparin in TNA may decrease the incidences of catheter obstruction and CRI.
