Roles of matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase and hs-CRP in Kawasaki disease.
- Author:
Rui CHEN
1
;
Ai-Rong ZHANG
;
Xin-Xi ZHAO
;
Zhan-Hua LI
Author Information
- Publication Type:Journal Article
- MeSH: C-Reactive Protein; analysis; Child; Child, Preschool; Female; Humans; Infant; Male; Matrix Metalloproteinase 2; blood; Matrix Metalloproteinase 9; blood; Mucocutaneous Lymph Node Syndrome; blood; etiology; Tissue Inhibitor of Metalloproteinase-1; blood
- From: Chinese Journal of Contemporary Pediatrics 2009;11(12):989-991
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the expression of matrix metalloproteinases (MMP)-2, -9, tissue inhibitor of matrix metalloproteinase (TIMP)-1 and hs-CRP, and their relationship with coronary artery in children with Kawasaki disease.
METHODSOne hundred and fifty-one children with Kawasaki disease (111 cases with coronary artery damage and 40 cases without) and 60 healthy children were enrolled. The expression of MMP-2, MMP-9 and TIMP-1 was detected using ELISA, and the hs-CRP concentration was measured using the endpoint nephelometry.
RESULTSThere were significant differences in the level of MMP-2, MMP-9 and hs-CRP between the patients with or without coronary artery damage and the healthy children (p<0.05). The levels of MMP-2, MMP-9 and hs-CRP were the highest in the cardiovascular damage group (p<0.05). There were positive correlations between MMP-2, MMP-9 and TIMP-1 in children with Kawasaki disease.
CONCLUSIONSMMP-2, MMP-9, TIMP-1 and hs-CRP may play important roles in the development of Kawasaki disease. The combined measurement of MMP-2, MMP-9 and hs-CRP may be useful in the evaluation of the severity in children with Kawasaki disease.
