A clinical study on Leucogen tablets therapy efficacy during PEGα-Interferon and α-Interferon in chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2012.02.011
- VernacularTitle:慢性乙型肝炎患者聚乙二醇α干扰素与α干扰素治疗中应用利可君的临床研究
- Author:
Hong-Fei ZHANG
1
;
Li-Min WANG
;
Yi DONG
;
XUZhi-qiang
;
Da-Wei CHEN
;
Yu GAN
;
Fu-Chuan WANG
;
Shi-Shu ZHU
Author Information
1. 解放军第302医院
- Keywords:
Hepatitis B,chronic;
Interferon-alpha;
Polyethylene glycols;
Neutropenia;
Leucogen tablets
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the efficacy of Leucogen tablets treatment lessen the hematological reaction and raise the efficacy therapy of interferon in chronic hepatitis B treated with PEG-αinterferon and α interferon.Methods A total of 395 patients with HBeAg-positive chronic hepatitis B (CHB) inpatients from January 2002 to February 2011.Group:All the patients were assigned to A or B according as during the treatment added Leucogen tablets or not.Results ( 1 ) All of 35.9％ patients had neutrophil counts decrease under 1 × 109/L,A group had 29.6％,B had 42.8％ patients,P =0.01 ;neutrophil counts≤0.75 × 109/L A group had 12.6％,B group had 26.4％,P =0.02; neutrophil counts≤ 0.5 × 109/L A group had 4.8 ％,B group had 16.4％,P =0.04.(2) A group had 8.2％ patients interferon-α dose decreased,all the patient finished the period of therapy.B group had 23.3％ patients interferon-α dose decreased,2.1％ of patients had paused.A group had 40.3％ of patients interferon-α beyond conventional dose,B group had only 5.2％.(3)All of 9.8％ patients had hematoblast decrease under 100 × 109/L,A group had 8.7％,B had 11.1％ patients;hematoblast≤ 80 × 109/L A group had 5.3％,B group had 7.9％ ;hematoblast ≤ 50 × 109/L A group had 1.0％,B group had 2.6％.A group had the trend of reducing hematoblast decrease.(4) At the end of therapy A group had 67.4％ patients HBVDNA ＜ 100IU/ml,54.3％ e antigen negative,40.7％ e antigen conversed; B group had 53.9％,41.2％,26.9％,P was respectively 0.02,0.01,0.01.Conclusion Leucogen tablets treatment and prevention interferon-α-related neutrophil counts hematological reaction in CHB treated with a-interferon,and had the trend of reducing interferon-αrelated hematoblast decrease,farther improved the efficacy of α-interferon treatment CHB.
