Efficacy of combination therapy with peginterferon alfa-2a and bicyclol in chronic hepatitis B with high ALT levels
10.3760/cma.j.issn.1003-9279.2012.02.012
- VernacularTitle:聚乙二醇干扰素α-2a联合双环醇治疗高转氨酶水平慢性乙型肝炎疗效初探
- Author:
Qin NI
1
;
Tian-Sheng XIE
;
Min-Wei LI
;
Ke-Zhou LIU
Author Information
1. 浙江大学医学院附属第一医院
- Keywords:
Hepatitis B Chronic;
Bicyclol compounds;
Interteron Alfa-2a;
Hepatitis/therapy
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(2):114-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of combination therapy with peginterferon alfa-2a (Pegasys) ±nucleos(t) ide analogues (NUC) and bicyclol in chronic hepatitis B with high ALT levels at baseline and during early treatment. Methods CHB patients were treated with PEG-IFNα-2a for a minimum of 48 weeks.All patients were followed up for 26 weeks post-treatment.Patients with HBV DNA ≥ 1 × 108 copies/ml were combined with NUC (adefovir or entecavir) treatment.Patients with ALT ＞ 500 U/L at baseline or ALT ＞ 300 U/L after first injection of PEG-IFNα-2a received bicyclol treatment for 1-2 months (treatment group).Patients with 2 × ULN ＜ ALT ＜ 300 U/L and ALT ＜ 300 U/L during treatment were enrolled into PEG-IFNα-2a ± NUC antiviral monotherapy (control group).Responses defined as HBV DNA ＜ 1 × 103 copies/ml,normal serum ALT,and HBeAg/HBsAg loss and seroconversion were analyzed at 26 weeks post-treatment.Results A total of 54 patients (44 HBeAg positive,10 HBeAg negative ) were divided into two groups according to combination of bieyclol:treatment group ( n =20 ) -those who received combinition therapy with PEG-IFNα-2a ± NUC and bicyclol,and control group (n =34 )-those who were treated with PEG-IFNα-2a ± NUC antiviral monotherapy.During the first month of treatment,ALT levels declined gradually in treatment group At 26 weeks post-treatment,the rates of ALT normalization and HBV DNA below the limit of 1 × 103 copies/ml were similar in both groups.Six patients in treatment group achieved HBsAg seroconversion at 26 weeks post-treatment,whereas so did 4 patients of control group(30％ vs.11.8％,P =0.044 ).Conclusion Bicyclol could significantly relief elevation of ALT induced by the IFN treatment.
