Determination of serum IL-23 and its significance in patients with severe chronic hepatitis B.
- Author:
Hai-Xia XU
1
;
Xue-Jun LI
;
Xing-Fei PAN
;
Qi-Huan XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alanine Transaminase; blood; Aspartate Aminotransferases; blood; DNA, Viral; analysis; Female; Hepatitis B, Chronic; immunology; virology; Humans; Interleukin-23; blood; Male; Middle Aged
- From: Chinese Journal of Experimental and Clinical Virology 2012;26(2):123-124
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the level of the serum IL-23 and its correlation with serum biochemical indices of liver function tests and HBV DNA load in patients with chronic severe hepatitis B.
METHODSFifty patients with chronic severe hepatitis B (severe hepatitis group) and 18 healthy controls (control group) were enrolled in the study. The serum IL-23 expression level was detected by ELISA method. The correlation between IL-23 and ALT, AST, TBil, HBV DNA load was analyzed using Pearson's correlation analysis, respectively.
RESULTSSerum IL-23 expression level in severe hepatitis group was significantly higher than that of control group (P < 0.05). Serum IL-23 level was positively correlated with serum ALT, AST, respectively (P < 0.05), but was not correlated with TBil and HBV DNA load, respectively (P > 0.05).
CONCLUSIONSerum IL-23 expression level was increased in patients with chronic severe hepatitis B and was associated with the severe of inflammation. We, therefore, believe that IL-23 might be involved in the pathogenesis of chronic severe hepatitis B.
