Determination of serum IL-23 and its significance in patients with severe chronic hepatitis B
10.3760/cma.j.issn.1003-9279.2012.02.015
- VernacularTitle:慢性重型乙型肝炎患者血清IL-23水平检测及其意义
- Author:
Hai-Xia XU
1
;
Xue-Jun LI
;
Xing-Fei PAN
;
Qi-Huan XU
Author Information
1. 湖北省仙桃市第一人民医院
- Keywords:
Interleakin-23;
Hepatitis B,chronic;
Serum response factor
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(2):123-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of the serum IL-23 and its correlation with serum biochemical indices of liver function tests and HBV DNA load in patients with chronic severe hepatitis B.Methods Fifty patients with chronic severe hepatitis B (severe hepatitis group) and 18 healthy controls (control group ) were enrolled in the study.The serum IL-23 expression level was detected by ELISA method.The correlation between IL-23 and ALT,AST,TBil,HBV DNA load was analyzed using Pearson's correlation analysis,respectively. Results Serum IL-23 expression level in severe hepatitis group was significantly higher than that of control group ( P ＜ 0.05).Serum IL-23 level was positively correlated with serum ALT,AST,respectively (P ＜ 0.05),but was not correlated with TBil and HBV DNA load,respectively ( P ＞ 0.05 ).Conclusion Serum IL-23 expression level was increased in patients with chronic severe hepatitis B and was associated with the severe of inflammation.We,therefore,believe that IL-23 might be involved in the pathogenesis of chronic severe hepatitis B.
