Prognostic analysis and establishment of a prognostic model for patients with liver failure with hepatorenal syndrome
10.3760/cma.j.issn.1003-9279.2012.02.017
- VernacularTitle:病毒性肝炎肝衰竭并肝肾综合征预后分析及预后模型的建立
- Author:
Ying YAN
1
;
Li MAI
;
Ying ZHANG
;
Yuan-Sen JIANG
;
Qi-Huan XU
Author Information
1. 中山大学附属第三医院
- Keywords:
Hepatitis B,chronic;
Hepatorenal syndrome;
Prognosis;
Models,statistical
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(2):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the factors that may influence the prognosis of patients with hepatorenal syndrome and try to establish a prognostic model.Methods Data of 126 patients with hepatorenal syndrome were analyzed and 56 indexes that might affect the prognosis were focused on,involving history,symptoms,signs and lab findings.Cox model and Kaplan-Meier survival analysis were used.Results Many factors were found to affect the prognosis independently, including hepatic encephalopathy (HE) and its degree,gastrointestinal bleeding( GIB ),blood neutrophil count (NI) and serum creatinine (Cr).The prognosis model was established as the following equation where PI represents prognosis index:PI =0.711HE + 0.836GIB + 0.052N1 + 0.002Cr ( GIB:no =0,yes =1 ; HE:no =0,phase Ⅰ =1,phase Ⅱ =2,phase Ⅲ =3,phase Ⅳ =4 ).When PI ＜ 1,the average survival time was 42 days; when 1 ≤ PI≤ 3,the average survival time was 15 days; when PI ＞ 3,the average survival time was 2 days.Conclusion The resuhs obtained from this study may help in estimation of diagnosis,analys01is of illness state and evaluation of therapy in clinical work.
