Value of combined detection of GP73 and alpha-fetoprotein in diagonosis of hepatocellular carcinoma.
- Author:
Qiao-Ping WU
1
;
Fu-Yi XIE
;
Qing-Ling MENG
;
Yin-Yu MU
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Humans; Liver Cirrhosis; blood; Liver Neoplasms; diagnosis; Male; Membrane Proteins; blood; alpha-Fetoproteins; analysis
- From: Chinese Journal of Experimental and Clinical Virology 2012;26(2):148-149
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the diagnostic value of the measurement of serum Golgi protein 73 (GP73) in the diagnosis of hepatocellular carcinoma (HCC).
METHODSEnzyme-linked immunosorbent assay (ELISA) was used to detect the serum GP73 in the 81 cases of HCC, 71 cases of chronic hepatitis or cirrhosis (CH/LC) and 65 cases of healthy blood donors, and to evaluate the sensitivity and specificity in the diagnosis of HCC through the ROC curves.
RESULTSThe average levels of serum GP73 in HCC, CH/LC and Normal groups were (152.67 +/- 33.59) ng/ml, (93.15 +/- 20.02) ng/ml and (58.95 +/- 17.29) ng/ml(o) After calculating through the ROC curves, 120 ng/ml was set as the optimal cut-off point, GP73 has a sensitivity of 77.80% and a specificity of 78.00%.
CONCLUSIONSGP73 as a serum marker in the diagnosis of HCC had a higher sensitivity than AFP, and the combined detection of GP73 and AFP could improve HCC diagnosis.
