Correlationship between chemokines and oxidative stress in chronic hepatitis B.
- Author:
Jing-Wei WANG
1
;
Li-Yuan WANG
;
Zhen-Hua ZHAO
;
Cheng-Bao WANG
;
Xing LIU
;
Li-Mei HUANG
;
Kai WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alanine Transaminase; blood; Chemokine CCL5; blood; Chemokine CXCL10; blood; Female; Glutathione; blood; Glutathione Disulfide; blood; Hepatitis B virus; genetics; isolation & purification; Hepatitis B, Chronic; blood; metabolism; virology; Humans; Male; Malondialdehyde; blood; Middle Aged; Oxidative Stress
- From: Chinese Journal of Experimental and Clinical Virology 2012;26(4):246-249
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe aim of this study is to investigate the possible associations of chemokines IP-10, Rantes and oxidative stress in chronic hepatits B (CHB).
METHODS70 CHB patients and 10 healthy controls were enrolled in the study. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of IFN-gamma-inducible protein-10 (IP-10) and regulated on activation normal T-cell-expressed and secreted (Rantes) and oxidative stress parameters (glutathione, GSH; glutathione disulfide, GSSG). Correlationship were analyzed by Spearman's rank correlation.
RESULTThe levels of IP-10 and Rantes were higher in CHB patients than healthy controls, and strong positive associations were found between IP-10/Rantes and alanine aminotransferase (ALT). The levels of GSH and GSH/GSSG were lower in CHB patients than healthy controls, and GSH and GSH/GSSG were negatively correlated with ALT. The levels of IP-10 and Rantes were negatively correlated with GSH and GSH/GSSG respectively.
CONCLUSIONStrong associations were found between chemokines and oxidative stress which participated in the pathogenesis of CHB.
