The characteristic of T cells response to HBV-specific antigen proteins in patients with HBV infection
10.3760/cma.j.issn.1003-9279.2012.04.004
- VernacularTitle:不同类型乙肝病毒感染者HBV抗原特异性T细胞免疫应答
- Author:
Xia FENG
1
;
Hui-Ping YAN
;
Hui-Yu LIAO
;
Yan-Min LIU
;
Guo-Yuan ZHANG
;
Fang LIN
;
Yan ZHAO
;
Yun-Li HUANG
Author Information
1. 首都医科大学附属北京佑安医院
- Keywords:
Hepatitis B;
Immunity,cellular;
Enzyme-linked immunospot assay
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(4):253-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristic of T cell response to specific antigen proteins in patients with hepatitis B virus infection.Methods 76 cases were recruited,including four groups,acute hepatitis B( AHB),active phase of chronic hepatitis B( CHB),inactive HBV carriers(AsC) and past HBV infection.T cell responses stimulated by 3 antigen specific proteins of HBV were detected using enzyme linked immunospot (ELISPOT) assay.Results (1)There were no significant difference in frequencies to HBsAg,HBcAg and HBeAg in AHB and CHB.The frequencies to HBsAg and HBcAg in AsC were lower than that to HBeAg,and the frequencies to HBsAg in group of past HBV infection were significantly lower than that to HBcAg and HBeAg.(2)The frequencies to HBsAg in AHB and CHB both were higher than in group of past HBV infection.The frequencies to HBcAg of AHB,CHB and AsC were higher than that of group of past HBV infection.(3)There were no significant difference in magnitude to HBsAg,HBcAg and HBeAg in AHB and AsC.In CHB,the magnitude to HBsAg was lower than that to HBcAg.The magnitude of in group of past HBV infection were HBcAg ＞ HBeAg ＞ HBsAg.(4) In four groups,the sequence of the magnitude to HBsAg from high to low was AHB,CHB,group of past HBV infection and AsC.The magnitude to HBcAg in of AsC was lower than other three groups.As to the magnitude to HBeAg,the difference was no significant between any two groups except between AHB and CHB.Conclusions The T cell responses in group of AsC to HBeAg were the highest,while the T cell responses to HBcAg were the highest in group of other groups.
