Expression and significance of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue.
- Author:
Bo SHEN
1
;
Jia CHEN
;
Ma-Qing ZHENG
;
Xin-Yu XU
;
Da WEI
;
Ji-Feng FENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; genetics; metabolism; pathology; Carcinoma; genetics; metabolism; pathology; Female; GPI-Linked Proteins; genetics; metabolism; Gene Expression Regulation, Neoplastic; Humans; Middle Aged; RNA, Messenger; genetics; metabolism; Receptor, ErbB-2; genetics
- From: Chinese Journal of Experimental and Clinical Virology 2012;26(4):279-281
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue and relationship with progression of breast carcinoma.
METHODS92 cases of breast carcinoma tissue and homologous paraneoplastic breast tissue were selected, expressive level of HER-2/neu mRNA and RECK mRNA were detected with RT-PCR, expressive difference of HER-2/neu mRNA and RECK mRNA were contrasted between breast carcinoma tissue and homologous paraneoplastic breast tissue, along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma.
RESULTSThe level of HER-2/neu mRNA was higher and RECK mRNA was lower in breast carcinoma tissue than homologous paraneoplastic breast tissue, the expressive level of HER-2/neu mRNA and RECK mRNA was remarkably different along with different TNM stage breast carcinoma tissue and differentiate breast carcinoma, there was a negative correlation between expressive level of HER-2/neu mRNA and RECK mRNA in breast carcinoma tissue.
CONCLUSIONSExpression of HER-2/neu mRNA and RECK mRNA was abnormal in breast carcinoma tissue, HER-2/neu mRNA and RECK mRNA regulate each other and mutual participate occurrence and progression of breast carcinoma.
