Clinical analysis of 134 cases of HEV-related liver failure.
- Author:
Bing ZHU
1
;
Shao-Li YOU
;
Hong ZANG
;
Yi-Hui RONG
;
Ai-Min ZHANG
;
Chen LI
;
Jing CHEN
;
Hong-Ling LIU
;
Zhi-Hong WAN
;
Shao-Jie XIN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Female; Hepatitis B; virology; Hepatitis B virus; isolation & purification; physiology; Hepatitis E; virology; Hepatitis E virus; isolation & purification; physiology; Humans; Liver Failure; virology; Male; Middle Aged; Retrospective Studies; Superinfection; virology; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2012;26(4):301-303
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical features of hepatitis E virus-related liver failure.
METHODS134 patients with HEV-related liver failure were analyzed retrospectively.
RESULTSHEV-related liver failure accounted for 8.45 percent of the total number of hepatitis E patients in the hospital. Of the 134 patients, 68 were infected with simple HEV, 66 had the superinfection with HBV. The average age of simple HEV-related liver failure patients (56.12 +/- 14.29) was higher than that of HBV superinfectiong liver failure patients (P < 0.05). The ratio of elderly patients (> or = 60 years) in simple HEV-related liver failure patients (45.59%) was significantly higher than that of the other group (13.64%, P < 0.05). The ratio of direct bilirubin/total bilirubing (0.72 +/- 0.07, 0.69 +/- 0.08), and serum alanine aminotransferase [(1250.90 +/- 1593.97) U/L, (616.26 +/- 797.62) U/L] were significantly higher in simple HEV-related liver failure patients than in HBV superinfectiong liver failure patients (P < 0.05), but the total bilirubing had no significant difference (P > 0.05). The disease outcome and stage were no-significant difference in the two groups (P > 0.05). CONCLUSION; Simple HEV-related liver failure patients may have older age, higher aminotransferase, higher ratio of direct bilirubin/total bilirubin, but disease outcome and stage were no-significant difference in the two groups.
