The analysis of human papillomavirus infection in lip squamous cell carcinoma patients

VernacularTitle:唇鳞状细胞癌患者人乳头瘤病毒感染的检测分析
Author: Wei WEI ¹ ; Bao-Yun ZHANG ; Yun-Tao SONG ; Jun-Yong SUN ; Cao CHEN ; Wen-Bin YU ; Guo-Hui XU ; Nai-Song ZHANG ; Xiao-Ping DONG ; Qi SHI
Author Information

1. 恶性肿瘤发病机制及转化研究教育部重点实验室
Keywords: Lip neoplasms; Carcinoma,squamous cell; Papillomavirus,human
From: Chinese Journal of Experimental and Clinical Virology 2012;26(5):356-358
CountryChina
Language:Chinese
Abstract: Objective To analyze the infection of human papillomavirus in lip squamous cell carcinoma patients.Methods The pathological samples of 9 clinical diagnosed lip cancer patients were collected.Lunimex and PCR techniques were used to detect the HPV gene infection and immunohistochemistry method was used to analyze the HPV protein expression in the samples.Results In the 9 cases,1 was positive for HPV16 gene and 7 were positive for HPV16/18 E6 protein expression.The total positive rate was about 8/9.Conclusion The high HPV infection rate in lip cancer patients in the study indicated indirectly that the importance of the direct contact to the infection of HPV what was the basis for pathogenesis of the lip squamous cell carcinoma.