Three-year efficacy and side effect of adefovir dipivoxil for the treatment of the old patients with chronic hepatitis B virus infection

VernacularTitle:阿德福韦酯治疗e抗原阴性慢性乙型肝炎病毒老年感染者的临床观察
Author: Meng-Fei ZHU ¹ ; Jian-Cheng QIAN ; Lu LU ; Feng-Le YAN ; Jun-Ping SHI ; Guo-Qiang LOU
Author Information

1. 310053,浙江中医药大学
Keywords: Adefovir dipivoxi; Hepatitis B; Health services for the aged
From: Chinese Journal of Experimental and Clinical Virology 2012;26(5):379-381
CountryChina
Language:Chinese
Abstract: Objective To investigate 3-year antiviral efficacy and side effect of adefovir dipivoxil (ADV) on the old patients with hepatitis B chronic infection.Methods 31 HBeAg-negative chronic hepatitis B virus infected old patients (include 8 patients with chronic hepatitis B and 23 patients with liver cirrhosis) with serum HBV DNA levels ＞ 1000 copies/ml,and ALT ＞ 2 times the upper limit of normal,without company with other liver diseases,cancer,renal dysfunction,and autoimmune disease.All the patients were treated with ADV orally (10 mg once daily) for 36 months.HBV DNA and biochemical and blood routine indexes were checked after treated.Result Serum total bilirubin,direct bilirubin,alamine aminotransferase,aspartate aminotransferase and load of HBV DNA decrease significantly after therapy (P ＜0.001).Other biochemical indexs and blood routine are no significant changes(P ＞ 0.05).Conclusion The way to treat with ADV is safe and effective for old patients with chronic hepatitis B virus infection.