Prior infected influenza virus could protect mice from challenge of lethal influenza virus.

Li-qi Liu; Zi LI; Yun Zhu; Yue-long Shu

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Prior infected influenza virus could protect mice from challenge of lethal influenza virus.

Author: Li-Qi LIU ¹ ; Zi LI ; Yun ZHU ; Yue-Long SHU
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1. Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, China CDC, WHO Collaborating Center for Reference and Research on Influenza, 155 Changbai Road, Bejing 102206, China.
Publication Type:Journal Article
MeSH: Animals; Antibodies, Viral; immunology; Female; Humans; Influenza A Virus, H1N1 Subtype; physiology; Influenza A Virus, H9N2 Subtype; physiology; Influenza, Human; immunology; prevention & control; virology; Lung; immunology; virology; Mice; Mice, Inbred BALB C; Viral Load
From: Chinese Journal of Experimental and Clinical Virology 2012;26(6):405-408
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo determine whether it could protect mice from challenge of lethal influenza virus which group prior infected A(H1N1) pdm09 and H9N2 virus respectively.
METHODS150 BALB/c mice are divided into three groups. Mice are infected A(H1N1) pdm09 virus (pCA07) and poultry H9N2 virus (GZ333) respectively. Infected mice are challenged with 10 times of lethal dose virus (PR8) then compare the viral load, antibody and survival of the two group mice before and after challenged.
RESULTSBoth experimental group mice survived after challenge of lethal influenza virus and lung viral load are lower than that of the first infection. Antibodies derived from the infective virus and challenge virus.
CONCLUSIONPrior infected A(H1N1) pdm09 and H9N2 virus could protect mice from challenge of lethal influenza virus.