Prior infected influenza virus could protect mice from challenge of lethal influenza virus
10.3760/cma.j.issn.1003-9279.2012.06.002
- VernacularTitle:小鼠感染流感病毒后可抵抗致死性流感病毒攻击的研究
- Author:
Li-Qi LIU
1
;
Zi LI
;
Yun ZHU
;
Yue-Long SHU
Author Information
1. 中国疾病预防控制中心病毒病预防控制所
- Keywords:
Influenza;
Influenza virus;
Cross infection
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(6):405-408
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine whether it could protect mice from challenge of lethal influenza virus which group prior infected A (H1N1) pdm09 and H9N2 virus respectively.Methods 150 BALB/c mice are divided into three groups.Mice are infected A(H1N1)pdm09 virus (pCA07) and poultry H9N2 virus (GZ333) respectively.Infected mice are challenged with 10 times of lethal dose virus (PR8) then compare the viral load,antibody and survival of the two group mice before and after challenged.Results Both experimental group mice survived after challenge of lethal influenza virus and lung viral load are lower than that of the first infection.Antibodies derived from the infective virus and challenge virus.Conclusion Prior infected A (H1N1)pdm09 and H9N2 virus could protect mice from challenge of lethal influenza virus.
