FibroScan can be used to diagnose the size of oesophageal varices in patients with HBV-related cirrhosis
10.3760/cma.j.issn.1003-9279.2012.06.021
- VernacularTitle:FibroScan技术判断乙型肝炎肝硬化患者食管静脉曲张程度的临床研究
- Author:
Fan LI
1
;
Tao YAN
;
Jian ZHANG
;
Qing SHAO
;
Bing LI
;
Zhong-Bing LI
;
Guo-Feng CHEN
Author Information
1. 解放军医学院
- Keywords:
Hepatitis B;
Liver cirrhosis;
Esophageal and gastric varices;
Diagnosis
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(6):470-473
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study ability of FibroScan (FS) in diagnosing the size of oesophageal varices (OV) in patients with HBV-related cirrhosis.Methods A total of 158 patients with HBV-related liver cirrhosis were enrolled in the study.The relation between the presence of OV assessed by endoscopy,and liver stiffness measurement by Fibroscan was studied,and ROC curves were drawn to assess the diagnostic ability of FS value.Results For the patients without OV,mild OV,moderate OV,and severe OV,their corresponding FS values were (21.7 ±9.9) kPa,(32.1 ± 13.6) kPa,(42.3 ±20.0) kPa and (54.5 ± 16.2) kPa,respectively.Significant difference was found among the groups (P ＜ 0.001) and also between any two groups (P ＜ 0.05).ROC curve for the diagnosis of with vs.without OV,＜ moderate vs.＞moderate OV,and ＜ severe vs.severe OV were 0.798 (95％ CI:73.1％-86.5％),0.823 (95％ CI:74.5％-90.0％)and 0.879 (95％ CI:80.8％-95.0％),respectively,with corresponding FS cut-off value of 23.3 kPa,31.5 kPa and 34.6 kPa.Conclusion Liver stiffness measurement allows to predict the sizes of oesophageal varices in patients with HBV-related cirrhosis.
