Diagnostic value and clinical significance of the Golgi protein-73 in hepatocellular carcinoma
10.3760/cma.j.issn.1003-9279.2012.06.024
- VernacularTitle:高尔基体蛋白-73对肝细胞癌的诊断价值与临床意义
- Author:
Qian-Feng SHI
1
;
Xin-Di PAN
;
Wei-Guo ZHANG
;
Wei-Fang SHAO
Author Information
1. 313100,浙江省长兴县人民医院检验科
- Keywords:
Carcinoma,hepatocellular;
Golgi apparatus;
Hepatitis,chronic;
Cirrhosis
- From:
Chinese Journal of Experimental and Clinical Virology
2012;26(6):480-482
- CountryChina
- Language:Chinese
-
Abstract:
Objective By the detection of hepatocellular carcinoma in patients with GP73 content to explore its significance for liver cancer diagnosis and clinical treatment.Methods Up-converting phosphor immunochromatography methods was used for detection of serum GP73 in 302 cases of liver cancer,chronic hepatitis,cirrhosis patients and normal control,application electrochemiluminescence detection of AFP as a comparison.And ROC curve analysis of its diagnostic performance,and patients with HCC before and after treatment GP73 periodic testing of the treatment effect.Results GP73 content of liver cancer patients was (160.83 ± 37.24) ng/ml,significantly higher than the chronic hepatitis,cirrhosis patients and normal controls.The area under ROC curve for GP73 diagonosis of hepatocellular carcinoma and chronic hepatitis and cirrhosis was 0.907 which higher than the area under the ROC curve of AFP was 0.727.Determine 110ng/ml most of its critical value,the sensitivity was 84.7％,specificity was 75.8％ ; liver cancer patients with AFP ＜ 400 ng/ml,detection rate of GP73 was 71.15％ ; the GP73 content after treatment showing an overall downward trend.Conclusion GP73 has a high sensitivity for the diagnosis of HCC can add to the AFP's lack of sensitivity that can be used to monitor liver cancer treatment.
