The preliminary study of HBV genotype distribution and the relationship with clinical manifestation.
- Author:
Jing SUN
1
;
Zhi-Yuan JIA
;
Jun-Xia CHANG
;
Wei LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; DNA, Viral; blood; genetics; Female; Genotype; Hepatitis B virus; genetics; Hepatitis B, Chronic; blood; virology; Humans; Liver Cirrhosis; blood; virology; Liver Neoplasms; blood; virology; Male; Middle Aged; Young Adult
- From: Chinese Journal of Experimental and Clinical Virology 2013;27(1):39-41
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between HBV genotypes distribution in hepatitis B patients and clinical manifestations in Beijing area.
METHODS200 HBsAg positive serum were choosen from 1148 serum samples. useing of nested PCR amplification method, HBV DNA S genes were Sequencing and typing; genotype distribution and the relationship with the clinical manifestation were Statistical analysis.
RESULTSIn Beijing area, HBV has B, C, D three genotypes, including B gene type 17 cases (12. 5%), C genotype 116 cases (85.2%), D genotype 3 cases (0.02%); in the carriers, patients with chronic hepatitis B, cirrhosis, liver cancer, B type have been gradually falling, C type have been gradually rising trend.
CONCLUSIONSerious liver disease relate with C type, B type patients with HBV infection is better than C type patients in clinical prognosis and antivirus treatment response.
