The preliminary study of HBV genotype distribution and the relationship with clinical manifestation in Beijing area
10.3760/cma.j.issn.1003-9279.2013.01.012
- VernacularTitle:北京地区HBV基因型的分布及其与临床表现关系的初步研究
- Author:
Jing SUN
1
;
Zhi-Yuan JIA
;
Jun-Xia CHANG
;
Wei LIU
Author Information
1. 101149,北京市通州区潞河医院
- Keywords:
Hepatitis B virus;
Genotype;
Polymerase chain reaction
- From:
Chinese Journal of Experimental and Clinical Virology
2013;27(1):39-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between HBV genotypes distribution in hepatitis B patients and clinical manifestations in Beijing area.Methods 200 HBsAg positive serum were choosen from 1148 serum samples.useing of nested PCR amplification method,HBV DNA S genes were Sequencing and typing; genotype distribution and the relationship with the clinical manifestation were Statistical analysis.Results In Beijing area,HBV has B,C,D three genotypes,including B gene type 17 cases (12.5％),C genotype 116 cases (85.2％),D genotype 3 cases (0.02％) ; in the carriers,patients with chronic hepatitis B,cirrhosis,liver cancer,B type have been gradually falling,C type have been gradually rising trend.Conclusion Serious liver disease relate with C type,B type patients with HBV infection is better than C type patients in clinical prognosis and antivirus treatment response.
