Electrophysiological effects of acehytisine hydrochloride in a porcine model of acute coronary occlusion.
- Author:
Yan LIANG
1
;
Jun ZHU
;
Yan-min YANG
;
Jian-dong LI
;
Yan SUN
;
Jian GUAN
;
Xin GAO
;
Chang-rui LI
;
Yue TANG
Author Information
- Publication Type:Journal Article
- MeSH: Aconitum; Animals; Coronary Disease; drug therapy; physiopathology; Disease Models, Animal; Drugs, Chinese Herbal; pharmacology; Electrophysiology; Female; Male; Phytotherapy; Random Allocation; Swine; Swine, Miniature
- From: Chinese Journal of Cardiology 2006;34(11):1035-1039
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the electrophysiological effect of Acehytisine Hydrochloride (AHH) in Wu Zhi Shan (WZS) micropigs with experimental acute coronary occlusion.
METHODSAdult WZS micropigs were randomized into group A: coronary ligation with AHH infusion (n = 9); group B: AHH infusion without coronary ligation (n = 9) and group C: coronary ligation with saline (NS) infusion (n = 9). Surface ECGs and cardiac electrophysiological data including atrium, atrium-ventricle junction and ventricle electrograms were collected by programmed electrical stimulation at ischemic baseline and after AHH (or NS) infusion.
RESULTSCompared to animals treated with AHH without ischemia, VARC-ERP was significantly increased while QT, QTc intervals, VRRP and VFRP were significantly reduced in ischemic animals treated with AHH. Compared to ischemic animals treated with saline, AHH prolongs the P-wave duration and PR interval, shortens QTc interval, prolongs ARP and AEP, also prolongs V-A reverse conduction time and VARC-ERP but shortens VFRP. No proarrhythmia effect was found in both AHH treated groups.
CONCLUSIONAHH resulted in significant electrophysiological effects on this porcine acute coronary ischemic model.