Procedural success and 10-month outcome between Cypher and TAXUS drug-eluting stents for the treatment of in-stent restenosis.
- Author:
Ji-Lin CHEN
1
;
Yue-Jin YANG
;
Shu-Bin QIAO
;
Min YAO
;
Xue-Wen QIN
;
Bo XU
;
Hai-Bo LIU
;
Yong-Jian WU
;
Jin-Qing YUAN
;
Jue CHEN
;
Shi-Jie YOU
;
Jun DAI
;
Jian-Jun LI
;
Run-Lin GAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Coronary Restenosis; therapy; Drug-Eluting Stents; Female; Follow-Up Studies; Graft Occlusion, Vascular; therapy; Humans; Male; Middle Aged; Paclitaxel; administration & dosage; therapeutic use; Sirolimus; administration & dosage; therapeutic use; Treatment Outcome
- From: Chinese Journal of Cardiology 2007;35(4):305-307
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the procedural success and 10-month outcome between sirolimus-eluting stent (Cypher stent) and paclitaxel-eluting stent (TAXUS stent) for the treatment of in-stent restenosis lesions.
METHODSPatients with in-stent restenosis treated with drug-eluting stents (DES) from December 2002 to March 2005 were included in this study and 10 months post stenting follow-up data were reported.
RESULTSA total of 253 patients with 262 in-stent restenosis lesions were treated with 176 Cypher and 132 TAXUS stents. There were 29 total occlusion, 143 > or = 90% stenosis and 90 < 90% stenosis lesions. Target lesion type distributions were as follows: 9 type A, 45 type B1, 73 type B2 and 135 type C lesions. The mean diameter in Cypher group (2.96 +/- 0.27) mm was smaller than that of TAXUS (3.05 +/- 0.35 mm, P = 0.041) and mean DES length was similar between the two groups (23.31 +/- 6.68 mm vs. 23.56 +/- 6.54 mm, P = 0.745). Procedural success rate of DES implantation was 100% for both Cypher and TAXUS groups. MACE rate during hospitalization was similar between the two groups. At 10-month follow up, MACE rate was significantly higher in TAXUS group than that in Cypher group (16.0% vs. 6.7% P = 0.031) and angiographic in-stent restenosis rate tended also higher in TAXUS group than that in Cypher group (29.4% vs. 14.0%, P = 0.075).
CONCLUSIONProcedural success rate was similar between Cypher and TAXUS groups and the angiographic and clinical outcome at 10 months was better in Cypher DES group than in TAXUS DES group.
