The clinical features and outcomes of immunoglobulin light-chain amyloidosis with heart involvement.
- Author:
Lei MENG
1
;
Wen-Hui DING
;
Li-Bin SHI
;
Yan-Jun GONG
;
Zhao-Ping LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Amyloidosis; diagnosis; pathology; Cardiomyopathies; diagnosis; pathology; Female; Humans; Immunoglobulin Light Chains; Male; Middle Aged; Prognosis; Retrospective Studies
- From: Chinese Journal of Cardiology 2007;35(4):340-343
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the clinical features and outcomes of patients with immunoglobulin light-chain amyloidosis (AL) who had heart involvement.
METHODSClinical features and outcomes of AL amyloidosis patients with heart involvement in the past 7 years in our hospital were retrospectively analyzed.
RESULTSCardiac involvement was seen in 36 out of the 60 AL patients (60%). The clinical manifestations of cardiac amyloidosis included heart failure (50%), low QRS voltage (47.2%) and pseudomyocardial infarction (33.3%) in electrocardiography, as well as thickening of ventricular wall (63.9%), echo of granular sparkling texture (11.1%), atria dilation (33.3%) and diastolic dysfunction (30.6%) in echocardiography. The prognosis was poor, with a median survival time of 13.9 months.
CONCLUSIONPatients of AL amyloidosis with cardiac involvement are not rare. Thickening of ventricular wall and diastolic dysfunction are the most common characteristics. Special attention should be paid to this disease.
