A new cytotoxic isocoumarin from endophytic fungus Aspergillus versicolor.
- Author:
Jie LUO
1
;
Li-Mei LI
1
;
Yue-de WANG
1
;
Kun ZHOU
1
;
Wei DONG
1
;
Yan-Qing YE
1
;
Xue-Mei GAO
1
;
Gang DU
1
;
Hai-Ying YANG
1
;
Qiu-Fen HU
1
;
Min ZHOU
1
Author Information
- Publication Type:Journal Article
- Keywords: Aspergillus versicolor; cytotoxicity; isocoumarins
- From: China Journal of Chinese Materia Medica 2016;41(1):92-95
- CountryChina
- Language:Chinese
- Abstract: A new isocoumarin, along with five known ones,were isolated from the fermentation products of an endophytic fungus Aspergillus versicolorby using various chromatographic techniques.Their structures were elucidated on the basis of extensivespectroscopic analysis, including 1D-and 2D-NMR techniques. Compound 1 was evaluated for cytotoxicity against five human tumor cell lines. The results showed that 1 exhibited weak cytotoxicityagainst NB4, SHSY5Y and MCF7 cells with IC₅₀ values of 6.8, 4.3,8.8 μmol•L⁻¹, respectively.
