Analysis on traditional Chinese medicine prescriptions treating cancer-related anorexia syndrome based on grey system theory combined with multivariate analysis method and discovery of new prescriptions.

Song-Lin CHEN; Cong CHEN; Hui ZHU; Jing LI; Yan PANG

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Analysis on traditional Chinese medicine prescriptions treating cancer-related anorexia syndrome based on grey system theory combined with multivariate analysis method and discovery of new prescriptions.

Author: Song-Lin CHEN ¹ ; Cong CHEN ² ; Hui ZHU ³ ; Jing LI ³ ; Yan PANG ³
Author Information

1. Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
2. Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
3. Department of Oncology, Tianjin People's Hospital, Tianjin 300121, China.
Publication Type:Journal Article
Keywords: cancer-related anorexia syndrome(CACS); grey screening method; prescription regularity
From: China Journal of Chinese Materia Medica 2016;41(2):314-320
CountryChina
Language:Chinese
Abstract: Cancer-related anorexia syndrome (CACS) is one of the main causes for death at present as well as a syndrome seriously harming patients' quality of life, treatment effect and survival time. In current clinical researches, there are fewer reports about empirical traditional Chinese medicine(TCM) prescriptions and patent prescriptions treating CACS, and prescription rules are rarely analyzed in a systematic manner. As the hidden rules are not excavated, it is hard to have an innovative discovery and knowledge of clinical medication. In this paper, the grey screening method combined with the multivariate statistical method was used to build the ″CACS prescriptions database″. Based on the database, totally 359 prescriptions were selected, the frequency of herbs in prescription was determined, and commonly combined drugs were evolved into 4 new prescriptions for different syndromes. Prescriptions of TCM in treatment of CACS gave priority to benefiting qi for strengthening spleen, also laid emphasis on replenishing kidney essence, dispersing stagnated liver-qi and dispersing lung-qi. Moreover, interdependence and mutual promotion of yin and yang should be taken into account to reflect TCM's holism and theory for treatment based on syndrome differentiation. The grey screening method, as a valuable traditional Chinese medicine research-supporting method, can be used to subjectively and objectively analyze prescription rules; and the new prescriptions can provide reference for the clinical use of TCM for treating CACS and the drug development.