Measurement of mass fraction of Sanjie Zhentong capsules with near infrared reflectance spectroscopy.
- Author:
Guang-ren ZHANG
;
Yun WU
;
Rui-ting JIN
;
Qin WAN
;
Jin-feng WU
;
Xiao-qian XU
;
Wei XIAO
- Publication Type:Journal Article
- MeSH:
Capsules;
chemistry;
Drugs, Chinese Herbal;
chemistry;
Least-Squares Analysis;
Spectroscopy, Near-Infrared;
methods
- From:
China Journal of Chinese Materia Medica
2015;40(16):3204-3208
- CountryChina
- Language:Chinese
-
Abstract:
Sanjie Zhentong capsules were scanned by using a near infrared spectra probe with different drug mass fraction and the spectral information of capsule shells and contents in it were obtained. Then partial least squares (PLS) models were developed for the prediction of mass fraction of Fritillariae Thunbergii Bulbus and Resine draconis in Sanjie Zhentong capsules. The correlation coefficient (r9c)) and root mean standard error( RMSEC) of 0.949 5, 0.958 2 and 4.742 4, 4.135 7. The models obtained correlation coefficient (r(v)) of 0.919 2, 0.936 7 and root mean square error (RMSECV) of 6.158 9, 5.037 3 respectively in the training set. The paired T test analysis of statistics showed that there were no significant difference between predictive values and measure values. The established models reflected a strong prediction performance and can meet the needs of the production.
