Chemical constituents from aerial part of Rehmannia glutinosa.
- Author:
Zhang LEI
;
Yan ZOU
;
Jie-kun XU
;
Jia ZHANG
;
Xian-sheng YE
;
Wei-ku ZHANG
;
Ping LIN
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
pharmacology;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
Humans;
Molecular Structure;
Plant Components, Aerial;
chemistry;
Rehmannia;
chemistry;
Spectrometry, Mass, Electrospray Ionization;
Triterpenes;
chemistry;
pharmacology
- From:
China Journal of Chinese Materia Medica
2015;40(16):3214-3219
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the chemical compounds from aerial part of Rehmannia glutinosa, six compounds were isolated and deter- mined by extensive spectroscopic analysis as(+)-(7S, 8S, 8'S)-9-O-[β-D-glucopyranoyl] asarininone(1), 2α,3β,19α,23-tetrahydroxy-olean-12-en-28-oic acid(2),7,3'-dihydroxyl-5'-methoxyisoflavone (3), aeginetic acid (4), corchorifattty acid B (5), pinellic acid (6). Among them, compound 1 was a new natural product. Compounds 2, 3 and 5 were obtained from the Rehmannia genus for the first time. In vitro study showed that none of the six compounds exhibited obvious activities to BEL-7402 and HCT-8 at the concentration of 10 mg x L(-1).
